1957

The CAT scanner is conceived

Allan MacLeod Cormack was seconded by the University of Cape Town to Groote Schuur Hospital as a nuclear physicist. Convinced there was a better way to measure the attenuation of X-rays passing through the body, he found it, subsequently publishing his algorithm in the Journal of Applied Physics (34: 2722-2727, 1963).

1979

Award of the Nobel Prize

Cormack and Godfrey Hounsfield shared the Nobel Prize in Medicine for their independent research that underpinned the development of computer assisted tomography. It was the first (and last) time they ever met. Cormack received the award from the King of Sweden. Click here for the full story.

1996

Counteracting diamond theft

De Beers, with annual revenues of over $6 billion, established that 20% of its uncut diamonds was being stolen by its own workers. It therefore developed a very low dose digital X-ray scanner to image the whole body.

1999

LODOX is used in medicine

The University of Cape Town and De Beers  secured $1.5 million in funding from the Innovation Fund to develop the LODOX (low dose X-ray) technology for medical applications. They set up a joint venture company, African Medical Imaging (Pty) Ltd, known as AMI, to exploit the technology for diagnostic imaging.

2002

LODOX is commercialised

De Beers spun out a separate company, Lodox Systems (Pty) Ltd, to focus explicitly on trauma applications. The next year it obtained regulatory approval from the Food & Drug Administration (FDA) and began to market its x-ray scanner system in the USA and elsewhere.

2003

Intellectual property is developed

AMI developed two key pieces of intellectual property (IP) based on Lodox technology: limited angle computer tomography and circular scanning digital mammography, and a United States patent (6,788,758) was subsequently awarded. AMI then became a shelf company in which the IP was located.

2005

Award of an NIH grant

Based on the IP developed by AMI, Kit Vaughan and Tania Douglas secured $275,000 in funding from the National Institutes of Health in the USA (R21CA101705) to develop the innovative mammography project for breast screening.

2008

Cormack’s biography is published

Kit published a biography on Allan Cormack, entitled Imagining the Elephant. The UCT team built a successful digital mammography system, published their findings in Physics in Medicine and Biology (54: 1533-1553, 2009) and developed a business plan to secure venture capital funding.

2009

Award of venture capital funding

Kit and his management team secured $2 million in venture capital funding from the IDC. The IDC purchased an equity stake in AMI, UCT retained a small stake and the balance was held by management and employees. Having been a shelf company for six years, AMI began operations again.

2010

CapeRay is launched

AMI changed its name to CapeRay Medical (Pty) Ltd. It registered the domain www.caperay.com and began to develop a new digital mammography system, incorporating the functions of a low dose digital x-ray machine and breast ultrasound, for which a provisional patent was registered.

2012

Award of ISO certification

CapeRay received certification to the quality management standards, ISO 9001 and ISO 13485, from SGS United Kingdom. The CE mark was also awarded for the Pandia digital X-ray camera, in compliance with Directive 93/42/EEC on medical devices. The company won an Innovation Award from the National Science and Technology Forum and successfully tested Soteria, its digital mammography system, in a clinical trial at Groote Schuur Hospital.

2014

Dual-modality tested in clinical trial

The Aceso system, incorporating both full-field digital mammography (FFDM) and automated breast ultrasound (ABUS), was successfully tested in a clinical trial at the University of Cape Town. There were 51 healthy volunteers and 7 patients with biopsy-proven breast cancer who participated, enabling CapeRay to demonstrate the considerable potential of dual-modality imaging.