In the end Orenstein elected not to undergo contralateral prophylactic mastectomy (CPM) but she did wonder just how prevalent the procedure was. Earlier this week she contributed a thoughtful, and thought-provoking, piece for The New York Times entitled “The wrong approach to breast cancer.” Orenstein cited a 2009 study published in the Journal of Clinical Oncology which showed that in women who underwent mastectomy to treat ductal carcinoma in situ, the rate of CPM had increased from 6.4% to 18.4% between 1998 and 2005. Researchers have characterised this spike as an “epidemic,” no doubt fuelled by patients’ fear of contracting a second cancer.
As we reported in two blogs last year, celebrities like the actress Angelina Jolie and ABC’s Amy Robach can have a significant impact on decisions made by ordinary women. Justifying her decision to opt for CPM, Robach argued, “I want to be at my daughters’ graduations. I want to be at their weddings. I want to hold my grandchildren.” Orenstein wasn’t convinced and sought further scientific evidence to elucidate the issue.published a follow-up study in the Journal of the National Cancer Institute in which they employed a decision analysis tree to predict survival outcomes after CPM. They concluded that the absolute 20-year survival benefit from CPM was less than 1%, irrespective of age, oestrogen receptor status or stage of cancer.
Doctors of course are not obliged to deliver treatment when this is deemed to be unnecessary, with Orenstein concluding, “The good news is that treatment to reduce the risk of metastasis has improved over the years. So, those of us who dream of dancing at our children’s weddings? We may yet get there. But if – when – we do, it won’t be because of CPM.”