These questions have been answered in a paper that has just been published online by the American Journal of Roentgenology. Elizabeth Dibble and her colleagues at Brown University conducted a retrospective study of 3,102 women, about half of whom underwent FFDM and the other half DBT, with all of them having either heterogeneously dense or extremely dense breast tissue (BI-RADS c or d). All women were reported as negative but were referred for follow-up screening with hand-held ultrasound (HHUS) because of their dense tissue.
Seen at left are the cranio-caudal and medio-lateral oblique FFDM images of a 65-year-old patient with heterogeneously dense breast tissue but no evidence of malignancy. Below right is the HHUS image which showed a 1.2 cm hypoechoic mass with indistinct margins, and an ultrasound-guided biopsy revealed an invasive lobular carcinoma (© American Roentgen Ray Society). The additional cancer detection rate for HHUS after FFDM was 3.5 per 1,000 women screened, and for HHUS after DBT it was 3.0 per 1,000 women. There was no statistical difference between these two findings.
“DBT does not obviate additional ultrasound screening in women with dense breast tissue. No evidence was found of a difference in additional cancer detection rate with screening ultrasound after FFDM versus after DBT,” commented Dibble. “Knowing that the cancer yield of screening ultrasound is similar may help inform clinical practice, because questions abound whether DBT is sufficient for screening women with dense breast tissue.”
While Skaane recently reported that DBT had a higher sensitivity than FFDM in dense breasts (71% vs 54%), Giuliani has shown that when automated breast ultrasound (ABUS) is added to FFDM, sensitivity reaches 97%. Furthermore, earlier this year, Said presented data to show that ABUS had a higher accuracy than DBT. All these findings are good news for CapeRay and its dual-modality Aceso system that combines FFDM and ABUS in the same platform.