{"id":6748,"date":"2018-02-23T09:59:31","date_gmt":"2018-02-23T07:59:31","guid":{"rendered":"https:\/\/www.caperay.com\/blog\/?p=6748"},"modified":"2018-02-23T09:59:31","modified_gmt":"2018-02-23T07:59:31","slug":"an-old-drug-grabs-new-attention","status":"publish","type":"post","link":"https:\/\/www.caperay.com\/blog\/an-old-drug-grabs-new-attention\/","title":{"rendered":"An Old Drug Grabs New Attention"},"content":{"rendered":"\n<!-- Facebook Like Button v1.9.6 BEGIN [http:\/\/blog.bottomlessinc.com] -->\n<iframe src=\"http:\/\/www.facebook.com\/plugins\/like.php?href=https%3A%2F%2Fwww.caperay.com%2Fblog%2Fan-old-drug-grabs-new-attention%2F&amp;layout=standard&amp;show_faces=false&amp;width=300&amp;action=like&amp;colorscheme=light&amp;font=arial\" scrolling=\"no\" frameborder=\"0\" allowTransparency=\"true\" style=\"border:none; overflow:hidden; width:300px; height: 30px; align: left; margin: 2px 0px 15px 0px\"><\/iframe>\n<!-- Facebook Like Button END -->\n<p><a href=\"https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Nature_cover_15Feb2018.jpg\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignright wp-image-6752 size-full\" src=\"https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Nature_cover_15Feb2018.jpg\" alt=\"\" width=\"350\" srcset=\"https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Nature_cover_15Feb2018.jpg 720w, https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Nature_cover_15Feb2018-300x208.jpg 300w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/a>The drug\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Thalidomide\" target=\"_blank\" rel=\"noopener noreferrer\">thalidomide<\/a>, given to pregnant women in the late 1950s, was responsible for serious birth defects that led to its withdrawal from the market. However, scientists subsequently discovered that thalidomide could be used successfully to treat\u00a0<a href=\"https:\/\/www.cancer.org\/cancer\/multiple-myeloma\/about\/what-is-multiple-myeloma.html\" target=\"_blank\" rel=\"noopener noreferrer\">multiple myeloma<\/a>\u00a0\u2013 cancer of white blood cells \u2013 and it is now in clinical trials for various types of cancer. Another \u201cold\u201d drug called\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Asparaginase\" target=\"_blank\" rel=\"noopener noreferrer\">L-asparaginase<\/a>, which has been used for decades to treat children with\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4936081\/\" target=\"_blank\" rel=\"noopener noreferrer\">acute lymphoblastic leukaemia<\/a>, has now been shown to have promise for the treatment of breast cancer patients.<\/p>\n<p>A team of scientists based at Cambridge University in the UK has just\u00a0<a href=\"https:\/\/www.nature.com\/articles\/nature25465\" target=\"_blank\" rel=\"noopener noreferrer\">published a paper<\/a>\u00a0in <em>Nature<\/em> that demonstrates the potential of L-asparaginase to prevent the spread of breast cancer cells. Using a mouse model, they discovered that an amino acid called\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Asparagine\" target=\"_blank\" rel=\"noopener noreferrer\">asparagine<\/a>\u00a0is essential for spreading the cells, and by restricting it, cancer cells were prevented from invading other parts of the body. The danger for breast cancer patients is\u00a0<a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/metastasis\" target=\"_blank\" rel=\"noopener noreferrer\">metatstasis<\/a>\u00a0\u2013 the spread of cells from the primary tumour site to the lung, bones and brain via the blood stream \u2013 so any treatment that prevents metastasis is fundamental to increasing survival.<\/p>\n<p><a href=\"https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Greg_Hannon.jpg\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignleft wp-image-6755 size-full\" src=\"https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Greg_Hannon.jpg\" alt=\"\" width=\"200\" srcset=\"https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Greg_Hannon.jpg 800w, https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Greg_Hannon-214x300.jpg 214w, https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Greg_Hannon-768x1076.jpg 768w, https:\/\/www.caperay.com\/blog\/wp-content\/uploads\/2018\/02\/Greg_Hannon-731x1024.jpg 731w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a>The researchers not only gave L-asparaginase to the mice, they also limited the amount of asparagine in the animals\u2019 food supply.\u00a0<a href=\"https:\/\/www.forbes.com\/sites\/victoriaforster\/2018\/02\/07\/sixty-year-old-drug-may-hold-the-key-to-stopping-spread-of-breast-cancer\/#1f5dd459423e\" target=\"_blank\" rel=\"noopener noreferrer\">According to<\/a>\u00a0the senior author, Greg Hannon (seen left): \u201cOur work has pinpointed one of the key mechanisms that promotes the ability of breast cancer cells to spread. When the availability of asparagine was reduced, we saw little impact on the primary tumour in the breast, but tumour cells had reduced capacity for metastases in other parts of the body.\u201d<\/p>\n<p>Their mouse studies prompted the researchers\u00a0<a href=\"https:\/\/www.sciencedaily.com\/releases\/2018\/02\/180207140359.htm\" target=\"_blank\" rel=\"noopener noreferrer\">to examine the data<\/a>\u00a0from breast cancer patients, which showed that the greater the ability of breast cancer cells to make asparagine, the greater the likelihood of the disease to spread. Interestingly, they also discovered that for several other cancer types, the increased ability of tumour cells to make asparagine was associated with reduced survival. Since asparagine is found in high quantities in dairy, soy, poultry and seafood, there is the possibility that dietary intervention, by cutting off the supply of nutrients essential to cancer\u2019s spread could help to restrain the tumour.<\/p>\n<p>The\u00a0<a href=\"https:\/\/www.sciencedaily.com\/releases\/2018\/02\/180207140359.htm\" target=\"_blank\" rel=\"noopener noreferrer\">next step<\/a>\u00a0will be to understand how these findings translate from the laboratory to patients. Given all the focus on new drugs, this research is\u00a0<a href=\"https:\/\/www.forbes.com\/sites\/victoriaforster\/2018\/02\/07\/sixty-year-old-drug-may-hold-the-key-to-stopping-spread-of-breast-cancer\/#1f5dd459423e\" target=\"_blank\" rel=\"noopener noreferrer\">a reminder<\/a>\u00a0that a successful treatment might already be right under our noses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The drug\u00a0thalidomide, given to pregnant women in the late 1950s, was responsible for serious birth defects that led to its [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_s2mail":"yes","_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[1],"tags":[13,14,16,22,35,54,94,95],"class_list":["post-6748","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-blood","tag-bone","tag-breast_cancer","tag-cells","tag-drug","tag-journal_article","tag-treatment","tag-tumour"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"The drug thalidomide, given to pregnant women in the late 1950s, was responsible for serious birth defects that led to its withdrawal from the market. However, scientists subsequently discovered that thalidomide could be used successfully to treat multiple myeloma \u2013 cancer of white blood cells \u2013 and it is now in clinical trials for various types of cancer.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"admin\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.caperay.com\/blog\/an-old-drug-grabs-new-attention\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"CapeRay blog - CapeRay news stories and articles about breast cancer diagnosis\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"An Old Drug Grabs New Attention - CapeRay blog\" \/>\n\t\t<meta property=\"og:description\" content=\"The drug thalidomide, given to pregnant women in the late 1950s, was responsible for serious birth defects that led to its withdrawal from the market. 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